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Article

Molecular Basis of the Recognition of the Active Rab8a by Optineurin.

Journal of molecular biology - 15 Nov 2024

Zhang Jing, Liu Lei, Li Miao, Liu Haobo, Gong Xinyu, Tang Yubin, Zhang Yuchao, Zhou Xindi, Lin Zhiqiao, Guo Hanbo, Pan Lifeng

Abstract excerpt

Optineurin (OPTN), a multifunctional adaptor protein in mammals, plays critical roles in many cellular processes, such as vesicular trafficking and autophagy. Notably, mutations in optineurin are directly associated with many human diseases, such as amyotrophic lateral sclerosis (ALS). OPTN can specifically recognize Rab8a and the GTPase-activating protein TBC1D17, and facilitate the inactivation of Rab8a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39374890
DOI: 10.1016/j.jmb.2024.168811

Genes

OPTN
TBC1D17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

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Molecular Basis of the Recognition of the Active Rab8a by Optineurin.PMID 39374890Read ↗

Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins.Semantic proximity Read ↗

Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylation.Semantic proximity Read ↗

Altered Functions and Interactions of Glaucoma-Associated Mutants of Optineurin.Semantic proximity Read ↗

Fundamental roles of the Optineurin gene in the molecular pathology of Amyotrophic Lateral SclerosisSemantic proximity Read ↗

Optineurin: A Coordinator of Membrane-Associated Cargo Trafficking and Autophagy.Semantic proximity Read ↗

Emerging views of OPTN (optineurin) function in the autophagic process associated with diseaseSemantic proximity Read ↗

Toward an integrative view of Optineurin functionsSemantic proximity Read ↗

Conformational stabilization of optineurin by the dynamic interaction of linear polyubiquitin.Semantic proximity Read ↗

Cellular Functions of Optineurin in Health and Disease.Semantic proximity Read ↗

Functional analysis of optineurin and some of its disease-associated mutants.Semantic proximity Read ↗

Role of Optineurin in the Mitochondrial Dysfunction: Potential Implications in Neurodegenerative Diseases and CancerSemantic proximity Read ↗

OPTN translocates to an ATG9A-positive compartment to regulate innate immune signalling and cytokine secretionSemantic proximity Read ↗

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