Article

Structure of the human FERRY Rab5 effector complex

2021-06-22

Abstract excerpt

Long-range mRNA transport is crucial for the spatio-temporal regulation of gene expression, and its malfunction leads to neurological disorders. The pentameric FERRY Rab5 effector complex is the molecular link between mRNA and early endosomes in mRNA intracellular distribution. Here, we determine the cryo-EM structure of the human FERRY complex, composed of Fy-1 to Fy-5. The structure reveals a clamp-like architec...

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Literature Corpus work: cc0ec6e6-f623-533b-afeb-108c2c9caaed
DOI: 10.1101/2021.06.21.449265

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