Article
Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5.
Nature communications - 14 Sept 2018
Jenkins Meredith L, Margaria Jean Piero, Stariha Jordan T B, Hoffmann Reece M, McPhail Jacob A, Hamelin David J, Boulanger Martin J, Hirsch Emilio, Burke John E
Abstract excerpt
The GTPase Rab11 plays key roles in receptor recycling, oogenesis, autophagosome formation, and ciliogenesis. However, investigating Rab11 regulation has been hindered by limited molecular detail describing activation by cognate guanine nucleotide exchange factors (GEFs). Here, we present the structure of Rab11 bound to the GEF SH3BP5, along with detailed characterization of Rab-GEF specificity. The structure of...
Topics
- Adaptor Proteins, Signal Transducing
- Crystallography
- Escherichia coli
- Guanine Nucleotide Exchange Factors
- Humans
- Molecular Structure
- Mutation
- Protein Binding
- rab GTP-Binding Proteins