Article
In vivo identification of GTPase interactors by mitochondrial relocalization and proximity biotinylation
2019-02-17
Abstract excerpt
The GTPases of the Ras superfamily regulate cell growth, membrane traffic and the cytoskeleton, and a wide range of diseases are caused by mutations in particular members. They function as switchable landmarks with the active GTP-bound form recruiting to the membrane a specific set of effector proteins. The GTPases are precisely controlled by regulators that promote acquisition of GTP (GEFs) or its hydrolysis to G...
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Identifiers and source
- Literature Corpus work
- ec88b1e1-b60b-532b-9a3a-4f484daa9ddc
- DOI
- 10.1101/553206