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Article

Structural basis of mRNA binding by the human FERRY Rab5 effector complex

1 Jun 2023

Abstract excerpt

The pentameric FERRY Rab5 effector complex is a molecular link between mRNA and early endosomes in mRNA intracellular distribution. Here, we determine the cryo-EM structure of human FERRY. It reveals a unique clamp-like architecture that bears no resemblance to any known structure of Rab effectors. A combination of functional and mutational studies reveals that while the Fy-2 C-terminal coiled-coil acts as...

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PMID: 37267906
DOI: 10.1016/j.molcel.2023.05.009

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