Article

Critical role for Piccolo in Synaptic Vesicle Retrieval

2018-05-24

Abstract excerpt

Loss of function of the presynaptic active zone protein Piccolo has recently been linked to a devastating disease causing brain atrophy. Here, we address how Piccolo inactivation adversely affects synaptic function and thus may contributes to neuronal loss. Our analysis shows that Piccolo is critical for the activity dependent recycling and maintenance of synaptic vesicles (SVs). Specifically, we find that boutons...

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Literature Corpus work: 242c377b-9534-5749-a62e-088b9f8ccd05
DOI: 10.1101/330050

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