Article

Enhancing the Discriminatory Power of ADHD and Autism Spectrum Disorder Polygenic Scores in Clinical and Non-Clinical Samples

2022-02-10

Abstract excerpt

<h4>Objective</h4> Polygenic scores (PGS) are widely used in psychiatric genetic associations studies due to their impressive power to predict focal outcomes. However, they lack in discriminatory power, in part due to the high degree of genetic overlap between psychiatric disorders. The lack of prediction specificity limits the clinical utility of psychiatric PGS, particularly for diagnostic applications. The goal...

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Literature Corpus work: d915786b-5af4-590c-98b4-9780135b0be6
DOI: 10.1101/2022.02.09.22270697

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