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Article

Leveraging genomic and transcriptomic data of diverse ancestry to uncover mechanisms of psychiatric risk in the adult and developing brain.

Nature communications - 29 Dec 2025

Jajoo Aarti, Balakundi Vijetha, Chatzinakos Chris, Aruldass Athina, Wen Cindy, Kolmans Ilse G C, Iatrou Artemis, Kleinman Joel E, Ressler Kerry J, Bigdeli Tim, Gandal Michael J, Daskalakis Nikolaos P

Abstract excerpt

We explore strategies to harness ancestral diversity in PsychENCODE Consortium Genotype-Expression (GEx) reference panels (adult and developing brain) and Psychiatric Genomics Consortium GWAS data to improve genetically regulated expression (GReX) models and their use for Transcriptome-wide association study (TWAS) discoveries, uncovering previously unknown aspects of psychiatric functional genomics. We trained...

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Bipolar Disorder
Brain
Major Depressive Disorder
Mental Disorders
Schizophrenia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Stress Disorders, Post-Traumatic

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PMID: 41461652
DOI: 10.1038/s41467-025-67941-9
PMCID: PMC12858809

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FLOT1
H4C13

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