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Article

Dysregulated DnaB unwinding induces replisome decoupling and daughter strand gaps that are countered by RecA polymerization.

Nucleic acids research - 8 Jul 2024

Behrmann Megan S, Perera Himasha M, Welikala Malisha U, Matthews Jacquelynn E, Butterworth Lauren J, Trakselis Michael A

Abstract excerpt

The replicative helicase, DnaB, is a central component of the replisome and unwinds duplex DNA coupled with immediate template-dependent DNA synthesis by the polymerase, Pol III. The rate of helicase unwinding is dynamically regulated through structural transitions in the DnaB hexamer between dilated and constricted states. Site-specific mutations in DnaB enforce a faster more constricted conformation that...

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Identifiers

PMID: 38808668
DOI: 10.1093/nar/gkae435
PMCID: PMC11229327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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