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Article

Transcriptional coupling and repair of 8-OxoG activate a RecA-dependent checkpoint that controls the onset of sporulation in Bacillus subtilis.

Scientific reports - 28 Jan 2021

Suárez Valeria P, Martínez Lissett E, Leyva-Sánchez Hilda C, Valenzuela-García Luz I, Lara-Martínez Reyna, Jiménez-García Luis F, Ramírez-Ramírez Norma, Obregon-Herrera Armando, Cuéllar-Cruz Mayra, Robleto Eduardo A, Pedraza-Reyes Mario

Abstract excerpt

During sporulation Bacillus subtilis Mfd couples transcription to nucleotide excision repair (NER) to eliminate DNA distorting lesions. Here, we report a significant decline in sporulation following Mfd disruption, which was manifested in the absence of external DNA-damage suggesting that spontaneous lesions activate the function of Mfd for an efficient sporogenesis. Accordingly, a dramatic decline in sporulation...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33510358
DOI: 10.1038/s41598-021-82247-8
PMCID: PMC7844254

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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