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Article

Myeloid Cell-Specific Deletion of LGR4 Suppresses Atherosclerotic Lesion Formation.

Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2026

Kathuria Ishita, Aithabathula Ravi Varma, Al Mamun Md Abdullah, Pervaiz Naveed, Neeli Indira, Ofosu-Boateng Malvin, Singh Udai P, Rairao Srija, Gyamfi Maxwell A, Kim Ki-Suk, Singla Bhupesh

Abstract excerpt

BACKGROUND: Monocyte-derived macrophages play a significant role in the initiation and progression of atherosclerosis by transforming into lipid-laden foam cells and regulating vascular inflammation. However, the molecular mechanisms that regulate macrophage lipid accumulation, phenotype, efferocytic capacity, and atherosclerosis are incompletely understood. Our preliminary studies revealed increased expression...

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Identifiers

PMID: 42389788
DOI: 10.1161/ATVBAHA.125.324159
PMCID: PMC13336305

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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