Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Myeloid-specific deficiency of pregnane X receptor decreases atherosclerosis in LDL receptor-deficient mice.

Journal of lipid research - 1 May 2020

Sui Yipeng, Meng Zhaojie, Park Se-Hyung, Lu Weiwei, Livelo Christopher, Chen Qi, Zhou Tong, Zhou Changcheng

Abstract excerpt

The pregnane X receptor (PXR) is a nuclear receptor that can be activated by numerous drugs and xenobiotic chemicals. PXR thereby functions as a xenobiotic sensor to coordinately regulate host responses to xenobiotics by transcriptionally regulating many genes involved in xenobiotic metabolism. We have previously reported that PXR has pro-atherogenic effects in animal models, but how PXR contributes to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atherosclerosis
Share to CD36 Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Foam Cells

Share to Gene Expression Regulation

Share to Lipids

Share to Macrophages

Share to Pregnane X Receptor

Share to Receptors, LDL

Source

Open in PubMed Open full text

Identifiers

PMID: 32170024
DOI: 10.1194/jlr.RA119000122
PMCID: PMC7193955

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Myeloid-specific deficiency of pregnane X receptor decreases atherosclerosis in LDL receptor-deficient mice.PMID 32170024Read ↗

Mechanisms and Therapeutic Advances of PXR in Metabolic Diseases and CancerSemantic proximity Read ↗

LDL Receptor–Related Protein-1Semantic proximity Read ↗

The Nuclear Xenobiotic Receptor Pregnane X Receptor: Recent Insights and New ChallengesSemantic proximity Read ↗

Beyond the Foam Cell: The Role of LXRs in Preventing AtherogenesisSemantic proximity Read ↗

Myeloid Cell-Specific Deletion of LGR4 Suppresses Atherosclerotic Lesion Formation.Semantic proximity Read ↗

PXR: More Than Just a Master Xenobiotic ReceptorSemantic proximity Read ↗

Krüppel-Like Factor 4 Regulation of Cholesterol-25-Hydroxylase and Liver X Receptor Mitigates Atherosclerosis SusceptibilitySemantic proximity Read ↗

Non-genomic effects of the Pregnane X Receptor negatively regulate platelet functions, thrombosis and haemostasisSemantic proximity Read ↗

NR4A1 (Nur77) deletion polarizes macrophages toward an inflammatory phenotype and increases atherosclerosis.Semantic proximity Read ↗

Inactivation of the LRP1 intracellular NPxYxxL motif in LDLR-deficient mice enhances postprandial dyslipidemia and atherosclerosis.Semantic proximity Read ↗

Hyperlipidemia induces typical atherosclerosis development in Ldlr and Apoe deficient rats.Semantic proximity Read ↗

Plasma high density lipoproteins: Therapeutic targeting and links to atherogenic inflammation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.