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Article

Lgr4 Governs a Pro-Inflammatory Program in Macrophages to Antagonize Post-Infarction Cardiac Repair.

Circulation research - 25 Sept 2020

Huang Chun-Kai, Dai Daopeng, Xie Hongyang, Zhu Zhengbin, Hu Jian, Su Min, Liu Mingyao, Lu Lin, Shen Weifeng, Ning Guang, Wang Jiqiu, Zhang Ruiyan, Yan Xiaoxiang

Abstract excerpt

RATIONALE: Macrophages are critically involved in wound healing following myocardial infarction (MI). Lgr4, a member of LGR (leucine-rich repeat-containing G protein-coupled receptor) family, is emerging as a regulator of macrophage-associated immune responses. However, the contribution of Lgr4 to macrophage phenotype and function in the context of MI remains unclear. OBJECTIVE: To determine the role of...

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PMID: 32600176
DOI: 10.1161/CIRCRESAHA.119.315807

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