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Article

GSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis

18 Feb 2023

Abstract excerpt

Abstract Pyroptosis, a type of Gasdermin-mediated cell death, contributes to an exacerbation of inflammation. To test the hypothesis that GSDME-mediated pyroptosis aggravates the progression of atherosclerosis, we generate ApoE and GSDME dual deficiency mice. As compared with the control mice, GSDME −/− /ApoE −/− mice show a reduction of atherosclerotic lesion area and inflammatory response when induced with a...

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PMID: 36807553
DOI: 10.1038/s41467-023-36614-w

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