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Article

Myeloid Krüppel-like factor 4 deficiency augments atherogenesis in ApoE-/- mice--brief report.

Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2012

Sharma Nikunj, Lu Yuan, Zhou Guangjin, Liao Xudong, Kapil Parul, Anand Puneet, Mahabeleshwar Ganapati H, Stamler Jonathan S, Jain Mukesh K

Abstract excerpt

OBJECTIVE: To investigate the role of Krüppel-like factor 4 (KLF4), an essential transcriptional regulator of macrophage polarization (M1/M2), in the pathogenesis of atherosclerosis. METHODS AND RESULTS: Despite the acknowledged importance of macrophages in atherosclerosis, the role of M1 (classically activated or proinflammatory) versus M2 (alternatively activated or anti-inflammatory) macrophages in this...

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Source

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Identifiers

PMID: 23065827
DOI: 10.1161/ATVBAHA.112.300471
PMCID: PMC3574634

Genes

KLF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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