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Article

Progranulin in the hematopoietic compartment protects mice from atherosclerosis.

Atherosclerosis - 1 Oct 2018

Nguyen Andrew D, Nguyen Thi A, Singh Rajesh K, Eberlé Delphine, Zhang Jiasheng, Abate Jess Porter, Robles Anatalia, Koliwad Suneil, Huang Eric J, Maxfield Frederick R, Walther Tobias C, Farese Robert V

Abstract excerpt

BACKGROUND AND AIMS: Progranulin is a circulating protein that modulates inflammation and is found in atherosclerotic lesions. Here we determined whether inflammatory cell-derived progranulin impacts atherosclerosis development. METHODS: Ldlr-/- mice were transplanted with bone marrow from wild-type (WT) or Grn-/- (progranulin KO) mice (referred to as Tx-WT and Tx-KO, respectively). RESULTS: After 10 weeks of...

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Identifiers

PMID: 30212683
DOI: 10.1016/j.atherosclerosis.2018.08.042
PMCID: PMC6432779

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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