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Article

Alzheimer's disease proteome-wide association study implicates adaptive immunity and identifies risk genes LILRB1 and SIRPA.

Science translational medicine - 1 Jul 2026

Walker Keenan A, Blew Cassandra, Duggan Michael R, Joynes Cassie, Gomez Gabriela T, Drouin Shannon, Cordon Jenifer, Chen Jingsha, Zhang Jingning, File Balint, Nanasi Tibor, Lehallier Benoit, Oh Hamilton, Surapaneni Aditya, Grams Morgan E, Palta Priya, Sullivan Kevin J, Pichet Binette Alexa, Wu Lang, Zhu Jingjing, Leonard Hampton, Singleton Andrew B, Fornage Myriam, Gottesman Rebecca F, Mosley Thomas H, Chatterjee Nilanjan, Boerwinkle Eric, Ferrucci Luigi, Coresh Josef, Schlosser Pascal

Abstract excerpt

The rapid expansion of plasma proteomic data and protein quantitative trait loci (pQTLs) provides an opportunity to identify genes that confer disease risk through their effect on plasma protein abundance. We conducted an Alzheimer's disease (AD) proteome-wide association study (PWAS) integrating publicly available plasma cis-pQTL data (1348 European American and 1385 African American genetically determined...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42384774
DOI: 10.1126/scitranslmed.adx4852

Genes

LILRB1
APOE
CD55
SCARA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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