Article

Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and informs causal proteins for Alzheimer’s disease

2023-06-09

Abstract excerpt

<title>Abstract</title> <p>The integration of quantitative trait loci (QTL) with disease genome-wide association studies (GWAS) has proven successful at prioritizing candidate genes at disease-associated loci. QTL mapping has mainly been focused on multi-tissue expression QTL or plasma protein QTL (pQTL). Here we generated the largest-to-date cerebrospinal fluid (CSF) pQTL atlas by analyzing 7,028 proteins in 3,1...

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Literature Corpus work: 363b6504-89c8-5fec-aa2d-a38e1ea5acf1
DOI: 10.21203/rs.3.rs-2814616/v1

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