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Article

Multivariate proteome-wide association study to identify causal proteins for Alzheimer disease.

American journal of human genetics - 6 Feb 2025

Fang Lei, Xue Haoran, Lin Zhaotong, Pan Wei

Abstract excerpt

Alzheimer disease (AD) is a complex and progressive neurodegenerative disorder that accounts for the majority of individuals with dementia. Here, we aim to identify causal plasma proteins for AD, shedding light on the etiology of AD. We utilized the latest large-scale plasma proteomic data from the UK Biobank Pharma Proteomics Project (UKB-PPP) and AD genome-wide association study (GWAS) summary data from the...

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Identifiers

PMID: 39793580
DOI: 10.1016/j.ajhg.2024.12.010
PMCID: PMC11866954

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