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Article

Genomics of Alzheimer's disease implicates the innate and adaptive immune systems.

Cellular and molecular life sciences : CMLS - 1 Dec 2021

Li Yihan, Laws Simon M, Miles Luke A, Wiley James S, Huang Xin, Masters Colin L, Gu Ben J

Abstract excerpt

Alzheimer's disease (AD) is a chronic neurodegenerative disease characterised by cognitive impairment, behavioural alteration, and functional decline. Over 130 AD-associated susceptibility loci have been identified by genome-wide association studies (GWAS), while whole genome sequencing (WGS) and whole exome sequencing (WES) studies have identified AD-associated rare variants. These variants are enriched in APOE,...

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Identifiers

PMID: 34708251
DOI: 10.1007/s00018-021-03986-5
PMCID: PMC11073066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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