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Proteome-wide analysis identifies plasma immune regulators of amyloid-beta progression

6 Jul 2024

Abstract excerpt

While immune function is known to play a mechanistic role in Alzheimer's disease (AD), whether immune proteins in peripheral circulation influence the rate of amyloid-β (Aβ) progression - a central feature of AD - remains unknown. In the Baltimore Longitudinal Study of Aging, we quantified 942 immunological proteins in plasma and identified 32 (including CAT [catalase], CD36 [CD36 antigen], and KRT19 [keratin...

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PMID: 38977137
DOI: 10.1016/j.bbi.2024.07.002

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