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Proteomics analysis of plasma from middle-aged adults identifies protein markers of dementia risk in later life

19 Jul 2023

Abstract excerpt

A diverse set of biological processes have been implicated in the pathophysiology of Alzheimer's disease (AD) and related dementias. However, there is limited understanding of the peripheral biological mechanisms relevant in the earliest phases of the disease. Here, we used a large-scale proteomics platform to examine the association of 4877 plasma proteins with 25-year dementia risk in 10,981 middle-aged adults....

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PMID: 37467317
DOI: 10.1126/scitranslmed.adf5681

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