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CSF proteogenomics implicates novel proteins and humoral immunity in Alzheimer’s disease risk

2025-09-22

Abstract excerpt

Identifying causal genes at Alzheimer’s Disease (AD) GWAS loci requires tissue-relevant functional genomic data. Cerebrospinal fluid (CSF) interfaces directly with the brain and can be obtained from living individuals, providing a potential proxy for brain protein biology at scale; however, large-scale CSF proteogenomic studies have been limited to affinity-based platforms. Here, we used mass spectrometry to profi...

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Literature Corpus work
897860b1-5847-5cc6-84e1-fb70af2e6903
DOI
10.1101/2025.09.21.25336297
Open publication

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CSF proteogenomics implicates novel proteins and humoral immunity in Alzheimer’s disease riskDOI 10.1101/2025.09.21.25336297
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