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Article

Proteomic Impact of Peripheral Expression of Mutant Huntingtin in C. elegans.

Journal of proteome research - 7 Aug 2026

Ezeigbo Ephraim, Stonebraker Alyssa, Yuliantoro Herbi, Adewoye Anjola, Debastiani Anthony, Roefer Emily, Biswas Pritom Kumar, Li Peng, Legleiter Justin, Valentine Stephen J

Abstract excerpt

Huntington's Disease (HD), a neurodegenerative disorder, is caused by the expansion of a polyglutamine (polyQ) tract near the N-terminus of the huntingtin protein (HTT), resulting in HTT aggregation. While associated with neurodegeneration, HTT is expressed ubiquitously throughout the body, leading to potential peripheral consequences of aggregation. However, the impact on peripheral tissues remains poorly...

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Identifiers

PMID: 42371730
DOI: 10.1021/acs.jproteome.5c00850

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HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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