Article

<i>C. elegans</i> huntingtin, <i>htt-1,</i> promotes robust autophagy induction and survival under stress conditions

2024-12-02

Abstract excerpt

Huntingtin (HTT) is the gene responsible for Huntington’s disease (HD), a neurodegenerative disorder caused by a CAG trinucleotide repeat expansion mutation. While HD pathogenesis has traditionally been attributed to the toxic gain-of-function effects of mutant huntingtin (mHTT), increasing evidence underscores the critical role of wild-type HTT loss-of-function. Understanding the physiological roles of HTT is ess...

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Literature Corpus work: aa94455a-b05d-5690-8180-088fef1287cf
DOI: 10.1101/2024.12.01.625591

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