Article
Reduced Insulin/IGF-1 Signaling Restores the Dynamic Properties of Key Stress Granule Proteins during Aging.
Cell reports - 10 Jan 2017
Lechler Marie C, Crawford Emily D, Groh Nicole, Widmaier Katja, Jung Raimund, Kirstein Janine, Trinidad Jonathan C, Burlingame Alma L, David Della C
Abstract excerpt
Low-complexity "prion-like" domains in key RNA-binding proteins (RBPs) mediate the reversible assembly of RNA granules. Individual RBPs harboring these domains have been linked to specific neurodegenerative diseases. Although their aggregation in neurodegeneration has been extensively characterized, it remains unknown how the process of aging disturbs RBP dynamics. We show that a wide variety of RNA granule...
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