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Proteome-based investigation of O-GlcNAcylation in a <i>C. elegans</i> model of Ageing and Alzheimer’s disease: Functional Support for Earlier Hypothesis-Generating Findings

2025-09-25

Abstract excerpt

The monosaccharide N-acetyl-glucosamine (GlcNAc), which dynamically modifies serine and threonine residues of nuclear and cytoplasmic proteins, is a key regulator of numerous biological processes. Investigating O-GlcNAc modification in vivo and in vitro remains challenging, making animal models essential for gaining powerful insights into this post-translational modification. In this study, we conducted a proteomi...

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Literature Corpus work
8d760cdf-2c10-5b7c-8678-9d1b20eaedd7
DOI
10.1101/2025.09.22.677859
Open publication

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Proteome-based investigation of O-GlcNAcylation in a <i>C. elegans</i> model of Ageing and Alzheimer’s disease: Functional Support for Earlier Hypothesis-Generating FindingsDOI 10.1101/2025.09.22.677859
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