Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Caenorhabditis elegans RNA-processing protein TDP-1 regulates protein homeostasis and life span.

The Journal of biological chemistry - 9 Mar 2012

Zhang Tao, Hwang Ho-Yon, Hao Haiping, Talbot Conover, Wang Jiou

Abstract excerpt

Transactive response DNA-binding protein (TARDBP/TDP-43), a heterogeneous nuclear ribonucleoprotein (hnRNP) with diverse activities, is a common denominator in several neurodegenerative disorders, including amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Orthologs of TDP-43 exist in animals ranging from mammals to invertebrates. Here, we systematically studied mutant Caenorhabditis elegans...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Animals, Genetically Modified

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caenorhabditis elegans

Share to Caenorhabditis elegans Proteins

Share to Forkhead Transcription Factors

Share to Frontotemporal Lobar Degeneration

Share to Homeostasis

Share to Longevity

Source

Open in PubMed Open full text

Identifiers

PMID: 22232551
DOI: 10.1074/jbc.M111.311977
PMCID: PMC3318719

Genes

TARDBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Caenorhabditis elegans RNA-processing protein TDP-1 regulates protein homeostasis and life span.PMID 22232551Read ↗

TDP-1/TDP-43 potentiates human α-Synuclein (HASN) neurodegeneration in Caenorhabditis elegansSemantic proximity Read ↗

RNA-Processing Protein TDP-43 Regulates FOXO-Dependent Protein Quality Control in Stress ResponseSemantic proximity Read ↗

TDP-1/TDP-43 Regulates Stress Signaling and Age-Dependent Proteotoxicity in Caenorhabditis elegansSemantic proximity Read ↗

Reduction of RAD23A extends lifespan and mitigates pathology in TDP-43 miceSemantic proximity Read ↗

Protective role of DNJ-27/ERdj5 in Caenorhabditis elegans models of human neurodegenerative diseases.Semantic proximity Read ↗

Reduction of RAD23A extends lifespan and mitigates pathology in TDP-43 miceSemantic proximity Read ↗

Neurotoxic effects of TDP-43 overexpression in C. elegans.Semantic proximity Read ↗

Phosphorylation Promotes Neurotoxicity in a<i>Caenorhabditis elegans</i>Model of TDP-43 ProteinopathySemantic proximity Read ↗

Major hnRNP proteins act as general TDP-43 functional modifiers both in Drosophila and human neuronal cellsSemantic proximity Read ↗

Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease modelsSemantic proximity Read ↗

Mutant TDP-43 and FUS cause age-dependent paralysis and neurodegeneration in C. elegans.Semantic proximity Read ↗

Mechanisms of aging-related proteinopathies in Caenorhabditis elegansSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.