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Article

Novel Molecular Insights into Leukemic Evolution of Myeloproliferative Neoplasms: A Single Cell Perspective.

International journal of molecular sciences - 3 Dec 2022

Rontauroli Sebastiano, Carretta Chiara, Parenti Sandra, Bertesi Matteo, Manfredini Rossella

Abstract excerpt

Myeloproliferative neoplasms (MPNs) are clonal disorders originated by the serial acquisition of somatic mutations in hematopoietic stem/progenitor cells. The major clinical entities are represented by polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), that are caused by driver mutations affecting JAK2, MPL or CALR. Disease progression is related to molecular and clonal...

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Identifiers

PMID: 36499582
DOI: 10.3390/ijms232315256
PMCID: PMC9740017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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