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Article

Single-cell methods in myeloproliferative neoplasms: old questions, new technologies.

Blood - 26 Jan 2023

O'Sullivan Jennifer Mary, Mead Adam J, Psaila Bethan

Abstract excerpt

Myeloproliferative neoplasms (MPN) are a group of clonal stem cell-derived hematopoietic malignancies driven by aberrant Janus kinase-signal transducer and activator of transcription proteins (JAK/STAT) signaling. Although these are genetically simple diseases, MPNs are phenotypically heterogeneous, reflecting underlying intratumoral heterogeneity driven by the interplay of genetic and nongenetic factors. Their...

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Identifiers

PMID: 36322938
DOI: 10.1182/blood.2021014668

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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