Article
HiJAKing the hematopoietic system: a low-frequency JAK2V617F clone drives myeloproliferative neoplasm pathology.
Blood - 13 Nov 2025
Bonal Dennis M, Oakes Alissa, Chorzalska Anna, Pardo Makayla, Petersen Max, Clarke Michael Y, Lee Seo-Ho, Olszewski Adam J, Treaba Diana O, Reagan John L, Dooner Mark, Morgan John, Bertone Paul, Zhao Ting C, Yang Wentian, Ventetuolo Corey E, Hobbs Gabriela S, Mills Joslyn, Dubielecka Patrycja M
Abstract excerpt
ABSTRACT: JAK2V617F is one of the most common mutations in clonal hematopoiesis of indeterminate potential (CHIP) and a major driver of myeloproliferative neoplasms (MPNs). To determine the impact of a low-frequency JAK2V617F clone on both the hematopoietic system and the bone marrow (BM) stroma, we developed a traceable murine MPN model, in which whole BM transplantation (BMT) was performed using CD45.2 5.0 ×...
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