Article
SATB2 dysregulation generates a novel circular RNA and drives KRAS-like transcriptional reprogramming and transformation-associated phenotypes.
Cell communication and signaling : CCS - 24 Jun 2026
Eleazer Rebekah, George Smitha, Shoemaker Luke J, Saintilnord Wesley N, Cassidy Richard N, Pyman Andrew, Lau Kin, Soper-Hopper Molly T, Lee Hyoungjoo, Chandler Darrell P, Fondufe-Mittendorf Yvonne N
Abstract excerpt
BACKGROUND: Even though epigenetic factors contribute to oncogenesis, most human cancer models still assume that disease originates from driver DNA mutations. Thus, it is still unclear if non-genetic mechanisms are sufficient to trigger malignant transformation. Special AT-rich binding protein 2 (SATB2) is a chromatin organizer that brings distal DNA elements into close proximity, thus remodeling chromatin...
Read the complete abstract on PubMedTopics
- Humans
- Matrix Attachment Region Binding Proteins
- Transcription Factors
- Phenotype
- Cell Transformation, Neoplastic