Article

BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous cell carcinoma

2017-11-22

Abstract excerpt

Patients diagnosed with lung squamous cell carcinoma (LUSC) have limited targeted therapeutic options. We report here the identification and characterisation of the transcriptional regulator, BCL11A , as a LUSC oncogene. Analysis of cancer genomics datasets revealed BCL11A to be upregulated in LUSC but not lung adenocarcinoma (LUAD). We demonstrated that knockdown of BCL11A in LUSC cell lines abolished xenograf...

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Literature Corpus work: 16bc7546-5745-5fa2-a605-1ab8c0f7fe1c
DOI: 10.1101/223776

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