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Arsenic disrupts H3K9me3 and H3K27me3 balance by biasing PRC2.1 and PRC2.2 activity via PALI1 inhibition in carcinogenesis

9 Jun 2025

Abstract excerpt

Inorganic arsenic (As 3+ ) is a well-established human carcinogen, yet the molecular mechanisms underlying its oncogenic potential remain incompletely understood.Here, we show that exposure to environmentally relevant concentrations of As³⁺ disrupts chromatin architectures in human bronchial epithelial cells (BEAS-2B) by discordantly regulating two key repressive histone modifications: histone H3 lysine 27...

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PMID: 40612682
DOI: 10.7150/ijbs.115605

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