Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

YAP-Activated SATB2 Is a Coactivator of NRF2 That Amplifies Antioxidative Capacity and Promotes Tumor Progression in Renal Cell Carcinoma

4 Jan 2023

Abstract excerpt

Aberrant epigenetic reprogramming contributes to the progression of renal cell carcinoma (RCC). Elucidation of key regulators of epigenetic reprogramming in RCC could help identify therapeutic vulnerabilities to improve treatment. Here, we report upregulation of the nuclear matrix-associated protein, special AT-rich binding protein-2 (SATB2), in RCC samples, which correlated with poor prognosis. SATB2 inhibition...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to FOXO transcription factor regulation
Share to Hippo pathway signaling and YAP/TAZ
Share to Renal cell carcinoma treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36598364
DOI: 10.1158/0008-5472.can-22-1693

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

YAP-Activated SATB2 Is a Coactivator of NRF2 That Amplifies Antioxidative Capacity and Promotes Tumor Progression in Renal Cell CarcinomaPMID 36598364Read ↗

SATB2 Expression in Human Tumors: A Tissue Microarray Study on More Than 15 000 TumorsSemantic proximity Read ↗

Chromatin remodeling (SWI/SNF) complexes, cancer, and response to immunotherapySemantic proximity Read ↗

Epigenetic modifiers: activities in renal cell carcinoma.Semantic proximity Read ↗

Integrative Clinical and Molecular Characterization of Translocation Renal Cell CarcinomaSemantic proximity Read ↗

Integrative genomics uncover mechanisms of renal medullary carcinoma transformation, microenvironment landscape and therapeutic vulnerabilitiesSemantic proximity Read ↗

PAX8 activates metabolic genes via enhancer elements in Renal Cell CarcinomaSemantic proximity Read ↗

EGR2-mediated regulation of m6A reader IGF2BP proteins drive RCC tumorigenesis and metastasis via enhancing S1PR3 mRNA stabilizationSemantic proximity Read ↗

Nuclear TARBP2 drives oncogenic dysregulation of RNA splicing and decaySemantic proximity Read ↗

SET1B drives sustained HIF activity and disease progression in clear cell renal cell carcinomaSemantic proximity Read ↗

SATB2 is a novel biomarker and therapeutic target for cancerSemantic proximity Read ↗

SATB2 and circ3915 RNA chromatin dysregulation drive <i>KRAS</i> -like oncogenic transformationSemantic proximity Read ↗

Computational analysis of protein-protein interactions of cancer drivers in renal cell carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.