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Article

Circ_0001839 modulates the oncogenic MYCL rs1038259890 (p.G83S) mutation to promote B[a]P-induced malignant transformation in 16HBE cells.

Journal of hazardous materials - 15 Feb 2026

Chen Xintong, Zhang Han, Yao Shuwei, Zhang Nan, Qiu Miaoyun, Li Saifeng, Huang Senhuang, Jia Yangyang, Lu Wenfeng, Zhong Chenghui, Yi Yanni, Zhou Yun, Jiang Yiguo

Abstract excerpt

Benzo[a]pyrene (B[a]P), a major representative of polycyclic aromatic hydrocarbons, has been confirmed by increasing evidence to possess strong mutagenic and carcinogenic properties. Genetic mutations are a central step in tumorigenesis, with driver mutations in oncogenes significantly contributing to cancer development. In this study, we investigated the genetic effects of environmental chemical exposure on...

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PMID: 41619596
DOI: 10.1016/j.jhazmat.2026.141279

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MYCL

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