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Article

SETBP1-R54P mutation promotes malignant transformation of cadmium-induced 16HBE cells by down-regulating circ_0007095 expression.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Jul 2025

Chen Wei, Liu Yufei, Li Meizhen, Wang Ye, Shang Kai, Li Rongxiang, Lin Qiuyi, Chen Yushan, Zeng Huixian, Ling Yihui, Qin Xiaodi, Hua Qiuhan, Zhang Yindai, Lin Tianshu, Zhou Yun, Jiang Yiguo

Abstract excerpt

Some cancers are strongly associated with exposure to environmental carcinogens, and genetic and epigenetic alterations are crucial in carcinogenesis. However, the interaction between genetic mutations and epigenetic regulation in cancer development has not been sufficiently examined. Here, we investigated the roles of gene mutations and altered circRNA expression in the malignant transformation of human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Epigenesis, Genetic

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Share to Kruppel-Like Factor 4

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Source

Identifiers

PMID: 40152245
DOI: 10.1093/toxsci/kfaf040

Genes

SETBP1
KLF4
PFKP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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