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Article

Cell-type resolved transcriptional network analysis of in vivo cellular senescence following injury.

PLoS computational biology - 1 Jun 2026

Sabalic Alda, Moiseeva Victoria, Cisneros Andres, Deryagin Oleg, Perdiguero Eusebio, Muñoz-Cánoves Pura, Garcia-Ojalvo Jordi

Abstract excerpt

Identifying the genetic correlates of complex phenotypes is a challenging task. Methods coming from the field of complex networks can help finding such molecular patterns, by revealing statistical associations among groups of genes that correlate with the phenotype. Here we study cellular senescence, a complex cell state whose molecular underpinnings are still under active investigation. We analyze cell...

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Identifiers

PMID: 42330039
DOI: 10.1371/journal.pcbi.1014429
PMCID: PMC13309044

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