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Article

The landscape of human tissue and cell type specific expression and co-regulation of senescence genes

9 Jan 2022

Abstract excerpt

BACKGROUND: Cellular senescence is a complex stress response that impacts cellular function and organismal health. Multiple developmental and environmental factors, such as intrinsic cellular cues, radiation, oxidative stress, oncogenes, and protein accumulation, activate genes and pathways that can lead to senescence. Enormous efforts have been made to identify and characterize senescence genes (SnGs) in stress...

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PMID: 35000600
DOI: 10.1186/s13024-021-00507-7

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