Exploring molecular signatures of senescence with marker, an R Toolkit for evaluating gene sets as phenotypic markers.

Abstract excerpt

Many biological processes, including cellular senescence, manifest as diverse phenotypes across cell types and conditions. Lacking definitive markers, researchers often rely on the expression of sets of genes to identify these complex states. However, multiple approaches exist to summarize gene set expression into quantitative metrics (i.e. signatures), each with distinct strengths and limitations, and we know of...

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