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Analysis of transcriptional modules during human fibroblast ageing

5 Nov 2020

Abstract excerpt

For systematic identification of transcription signatures of human cell aging, we carried out Weighted Gene Co-expression Network Analysis (WGCNA) with the RNA-sequencing data generated with young to old human dermal fibroblasts. By relating the modules to the donor's traits, we uncovered the natural aging- and premature aging disease-associated modules. The STRING functional association networks built with the...

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Share to Genetics, Aging, and Longevity in Model Organisms
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PMID: 33154459
DOI: 10.1038/s41598-020-76117-y

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