Integration of transcriptomes of senescent cell models with multi-tissue patient samples reveals reduced COL6A3 as an inducer of senescence.

doi:10.1016/j.celrep.2023.113371

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Integration of transcriptomes of senescent cell models with multi-tissue patient samples reveals reduced COL6A3 as an inducer of senescence.

Cell reports - 28 Nov 2023

Savić Radoslav, Yang Jialiang, Koplev Simon, An Mahru C, Patel Priyanka L, O'Brien Robert N, Dubose Brittany N, Dodatko Tetyana, Rogatsky Eduard, Sukhavasi Katyayani, Ermel Raili, Ruusalepp Arno, Houten Sander M, Kovacic Jason C, Stewart Andrew F, Yohn Christopher B, Schadt Eric E, Laberge Remi-Martin, Björkegren Johan L M, Tu Zhidong, Argmann Carmen

Abstract excerpt

Senescent cells are a major contributor to age-dependent cardiovascular tissue dysfunction, but knowledge of their in vivo cell markers and tissue context is lacking. To reveal tissue-relevant senescence biology, we integrate the transcriptomes of 10 experimental senescence cell models with a 224 multi-tissue gene co-expression network based on RNA-seq data of seven tissues biopsies from ∼600 coronary artery...

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PMID: 37938972
DOI: 10.1016/j.celrep.2023.113371
PMCID: PMC10955802

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