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Mathematical Modeling of MPNs Offers Understanding and Decision Support for Personalized Treatment

30 Jul 2020

Abstract excerpt

(1) Background: myeloproliferative neoplasms (MPNs) are slowly developing hematological cancers characterized by few driver mutations, with JAK2V617F being the most prevalent. (2) Methods: using mechanism-based mathematical modeling (MM) of hematopoietic stem cells, mutated hematopoietic stem cells, differentiated blood cells, and immune response along with longitudinal data from the randomized Danish DALIAH...

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PMID: 32751766
DOI: 10.3390/cancers12082119

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