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Article

Determining the role of inflammation in the selection of JAK2 mutant cells in myeloproliferative neoplasms

2016-10-04

Abstract excerpt

Myeloproliferative neoplasm (MPN) is a hematologic malignancy characterized by the clonal outgrowth of hematopoietic cells with a somatically acquired mutation most commonly in JAK2 (JAK2 V 617 F ). This mutation endows upon myeloid progenitors cytokine independent growth and consequently leads to excessive production of myeloid lineage cells. It has been previously suggested that inflammation may play a role in...

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Literature Corpus work
81729cef-0a35-5a16-8750-0249ebf80afe
DOI
10.1101/079020
Open publication

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Determining the role of inflammation in the selection of JAK2 mutant cells in myeloproliferative neoplasmsDOI 10.1101/079020
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