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Article

Determining the role of inflammation in the selection of JAK2 mutant cells in myeloproliferative neoplasms.

Journal of theoretical biology - 21 Jul 2017

Zhang Jie, Fleischman Angela G, Wodarz Dominik, Komarova Natalia L

Abstract excerpt

Myeloproliferative neoplasm (MPN) is a hematologic malignancy characterized by the clonal outgrowth of hematopoietic cells with a somatically acquired mutation most commonly in JAK2 (JAK2V617F). This mutation endows upon myeloid progenitors cytokine independent growth and consequently leads to excessive production of myeloid lineage cells. It has been previously suggested that inflammation may play a role in the...

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Source

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Identifiers

PMID: 28501635
DOI: 10.1016/j.jtbi.2017.05.012
PMCID: PMC5689470

Genes

JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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