Chr15q25 genetic variant (rs16969968) independently confers risk of lung cancer, COPD and smoking intensity in a prospective study of high-risk smokers.

doi:10.1136/thoraxjnl-2020-214839

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Article

Chr15q25 genetic variant (rs16969968) independently confers risk of lung cancer, COPD and smoking intensity in a prospective study of high-risk smokers.

Thorax - 1 Mar 2021

Hopkins Raewyn J, Duan Fenghai, Gamble Greg D, Chiles Caroline, Cavadino Alana, Billings Paul, Aberle Denise, Young Robert P

Abstract excerpt

IMPORTANCE: While cholinergic receptor nicotinic alpha 5 (CHRNA5) variants have been linked to lung cancer, chronic obstructive pulmonary disease (COPD) and smoking addiction in case-controls studies, their corelationship is not well understood and requires retesting in a cohort study. OBJECTIVE: To re-examine the association between the CHRNA5 variant (rs16969968 AA genotype) and the development of lung cancer,...

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PMID: 33419953
DOI: 10.1136/thoraxjnl-2020-214839

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