Article
Genetic Risk Can Be Decreased: Quitting Smoking Decreases and Delays Lung Cancer for Smokers With High and Low CHRNA5 Risk Genotypes - A Meta-Analysis.
EBioMedicine - 1 Sept 2016
Chen Li-Shiun, Baker Timothy, Hung Rayjean J, Horton Amy, Culverhouse Robert, Hartz Sarah, Saccone Nancy, Cheng Iona, Deng Bo, Han Younghun, Hansen Helen M, Horsman Janet, Kim Claire, Rosenberger Albert, Aben Katja K, Andrew Angeline S, Chang Shen-Chih, Saum Kai-Uwe, Dienemann Hendrik, Hatsukami Dorothy K, Johnson Eric O, Pande Mala, Wrensch Margaret R, McLaughlin John, Skaug Vidar, van der Heijden Erik H, Wampfler Jason, Wenzlaff Angela, Woll Penella, Zienolddiny Shanbeh, Bickeböller Heike, Brenner Hermann, Duell Eric J, Haugen Aage, Brüske Irene, Kiemeney Lambertus A, Lazarus Philip, Le Marchand Loic, Liu Geoffrey, Mayordomo Jose, Risch Angela, Schwartz Ann G, Teare M Dawn, Wu Xifeng, Wiencke John K, Yang Ping, Zhang Zuo-Feng, Spitz Margaret R, Amos Christopher I, Bierut Laura J
Abstract excerpt
BACKGROUND: Recent meta-analyses show that individuals with high risk variants in CHRNA5 on chromosome 15q25 are likely to develop lung cancer earlier than those with low-risk genotypes. The same high-risk genetic variants also predict nicotine dependence and delayed smoking cessation. It is unclear whether smoking cessation confers the same benefits in terms of lung cancer risk reduction for those who possess...
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