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Article

A fusion-deletion genomic-event underlies poor prognosis in young patients with luminal breast cancer.

PloS one - 1 Jan 2026

Zheng Le-Wei, Liu Yi-Ming, Yu Ke-Da, Liu Cui-Cui

Abstract excerpt

Breast cancer in young patients, particularly those with the luminal subtype, exhibits more aggressive behavior and poorer clinical outcomes compared with older patients. However, the genomic mechanisms underlying this age-associated aggressiveness remains poorly understood. In this study, we integrated multi-omics data, including gene fusions, mutations, and copy number variations, to investigate age-related...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42302066
DOI: 10.1371/journal.pone.0349410
PMCID: PMC13271521

Genes

DNM3
KDM6B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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