Article
Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Jul 2008
Anders Carey K, Hsu David S, Broadwater Gloria, Acharya Chaitanya R, Foekens John A, Zhang Yi, Wang Yixin, Marcom P Kelly, Marks Jeffrey R, Febbo Phillip G, Nevins Joseph R, Potti Anil, Blackwell Kimberly L
Abstract excerpt
PURPOSE: Breast cancer arising in young women is correlated with inferior survival and higher incidence of negative clinicopathologic features. The biology driving this aggressive disease has yet to be defined. PATIENTS AND METHODS: Clinically annotated, microarray data from 784 early-stage breast cancers were identified, and prospectively defined, age-specific cohorts (young: </= 45 years, n = 200; older: >/= 65...
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