Whole genome sequencing of locally advanced and metastatic breast carcinoma unravels relevant molecular signatures and novel events.

doi:10.1016/j.prp.2026.156469

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Article

Whole genome sequencing of locally advanced and metastatic breast carcinoma unravels relevant molecular signatures and novel events.

Pathology, research and practice - 1 Jun 2026

Kozan Eda Nur, Delgado-de la Mora Jesús, Al Assaad Majd, Ginter Paula, Gundem Gunes, Levine Max F, Gorski Kathryn, Phan Andy, Beg Shaham, Sigaras Alexandros, LaPolla Dayle, Semaan Alissa, Wilkes David C, Greco Noah, Sigouros Michael, Manohar Jyothi, Medina-Martínez Juan S, Sboner Andrea, Elemento Olivier, Hoda Syed, Saxena Ashish, Andreopoulou Eleni, Boyraz Baris, Mosquera Juan Miguel

Abstract excerpt

Metastatic breast cancer remains the leading cause of cancer related mortality in women. While comprehensive genomic profiling of primary tumors has advanced, the whole genome landscape of metastatic disease remains incompletely characterized. We performed whole genome and transcriptome sequencing on 50 tumor samples from 37 patients with locally advanced or metastatic breast cancer. Based on...

Read the complete abstract on PubMed